Formulation and In-Vitro Penetration Test of Ketoconazole Nanoemulsion

This study was aimedto formulate ketoconazole into nanoemulsionformandtocomparedthe penetrationabilityof each formula with ketoconazole cream on the marketas control. Formulationof nanoemulsionuses spontaneous methods and and also measurement of particleusing the Particle Size Analyzer (PSA). In vitro penetration test usedFranz diffusion cells. The results showed that nanoemulsionofeach formula had different particle sizes, it was due to the distressof homogenizing two different systems, the duration and speed of stirring also affectthe homogenity. The higherconcentration of surfactant (tween 80) inthe nanoemulation preparation could increasing the penetration ability of the preparation, but if the concentration exceeds the critical micelle concentration (CMC), a tight surfactant matrix (tween 80) will be formed which causes the release of ketoconazole to be slowed. Based on the observation, the highest penetration test was formula F3 as many as4,268.01 μg/cm